Atrionatriuretic peptide and calcium-conducting sodium channels
نویسندگان
چکیده
منابع مشابه
Cardiac sodium and calcium channels: a history of excitatory currents.
The entire concept of ion channels as molecular machines to gate ion traffic across the membrane has only recently been generally recognized, even though ion channels are found in almost all cells. Na+ and Ca2+ channels are the basis of excitability, and in the heart they generate the rhythm, coordinating and controlling cardiac contraction. Dysfunction of ion channels results in arrhythmias th...
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NALCN is a member of the family of ion channels with four homologous, repeat domains that include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene from simple, extant multicellular organisms without nervous systems such as sponges and placozoans and mostly remains a single gene compared to the calcium and sodium channels which diversified into twenty genes in humans. ...
متن کاملDifferential effects of membrane perturbants on voltage-activated sodium and calcium channels and calcium-dependent potassium channels.
Biol. 82:559-564. 6. Hiwatashi, K., N. Haga, and M. Takahashi. 1980. Restoration of membrane excitability in a behavioral mutant of Paramecium caudatum during conjugation and by microinsection wild-type cytoplasm. J. Cell Biol. 84:476-480. 7. Haga, N., Y. Saimi, M. Takahashi, and C. Kung. 1983. Intraand inter-specific complementation of membrane-inexcitable mutants of Paramecium. J. Cell Biol. ...
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Voltage-gated sodium channels underlie the rapid regenerative upstroke of action potentials and are modulated by cytoplasmic calcium ions through a poorly understood mechanism. We describe the 1.35 Å crystal structure of Ca(2+)-bound calmodulin (Ca(2+)/CaM) in complex with the inactivation gate (DIII-IV linker) of the cardiac sodium channel (Na(V)1.5). The complex harbors the positions of five ...
متن کاملModulation of L-type calcium channels by sodium ions.
It is universally believed that the removal of external sodium ions is without effect on calcium current. We now report that in enzymatically isolated guinea pig ventricular cells, the replacement of external sodium ions with certain other cations causes a 3- to 6-fold increase in peak L-type calcium current. The increase in current is reversibly blocked by L-type calcium-channel antagonists, n...
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ژورنال
عنوان ژورنال: Science
سال: 1991
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1850170